Category: trading

Overseas Shipping – Bringing The World Closer Together

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In the 21st Century, the world is new and different from what it used to be a few decades ago. There are number of improvement that has taken place regarding international shipping. Number of International shipping companies have emerged giving contemporary services for International Moving Items, Container shipping etc.

Overseas shipping business has become triumphant, easier and extra money spinning. It is candidly seen that cell phones, blackberries, Laptops and GPS tracking have enabled us to be additional manageable having freedom to do business in places we were never proficient to before. We are one of the well renowned International Shipping Company providing state-of-the-art overseas shipping services.

Trade policies that were put in place during the 20th Century have benefited overseas shipping companies like us doing business on an international scale quicker and better organized. The North American Free Trade Act assist companies in the United States, Canada and Mexico exchanging goods and services without hold ups or high income and export taxes. Treaties established with the nations of Southeast Asia after World War II have enabled us to send expertise, textiles and automobiles back and forth transversely the Pacific.

Building a website in the United States and selling a product to the rest of the world is a common incidence for even those who have never been in business for themselves before. Utilizing local or remote manufacturers and a realistic overseas shipping method, number of people has become triumphant overnight. Outsourcing the manufacturing or administration of it can make a good idea an automatic income with incredibly little effort on the part of the owner.

Technology has not just profited the overseas shipping industry. It has brought the world nearer together and has given us hope for the future. For thousands of years individuals and nations have fought for the right to arrange overseas shipping markets and routes. For example, United States struggled for two centuries just to increase power of the continent that they are physically located on. The Internet is a state that is big enough for everyone. Products can be sold to the full world and the overseas shipping routes can be shared by companies delivering products to all nations.

Using a shipping company like us will always a significance giving enormous deal with peace of mind. There are number of issues, which could be simply covered with us, so it is very important that you would be entirely relaxed with us. In spite of everything, your belongings may have taken a lifetime to collect, they may have enormous sentimental value, and they are not something that you can hand over to just any shipping company. We give full pledge that if you hire us; your belongings will reach to their objective very well. 6103 Obispo Ave, Long Beach, CA 90805

Categories: trading

How Import & Export Consultants Can Help Your Trading Business?

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Consultant or advisors are experts having ample knowledge about a specific industry, field, or market. Knowing the ins and outs of some particular industry means that they are well equipped to help their clients, especially those who are relatively new in this field. You can also think of hiring a consultant, when you don’t have enough time to personally look after some important project, or you can hire these consultants to train your staff.

Import and export consultants are specifically helpful when you are looking to trade in new emerging markets like the big four (Brazil, China, Russia, and India). Markets like China or India may provide real business opportunities, but for a new comer, it is not a walk in the park to go and start trading with Chinese suppliers, manufacturers, exporters, or distributors. If wholesale import and export was that simple, everybody would be doing it, since it can open a floodgate of opportunities for all kinds of businesses. What actually keeps all kinds of businesses from jumping into international trade are a number of obstructions. To start importing, one needs to have ample information about the documentation, laws, custom duties, etc, and that is where an import & export consultants comes handy.

One option is to gather all sorts of information from the sources like internet, material published by the chamber of commerce, government authorities, and try to learn the ins and outs of international trade. However it will take a lot of time, and sometimes one doesn’t have that much time to learn each and everything by themselves. Very few wholesale traders have this much time to go through booklets, research reports, and government policies themselves. And that’s not all, in addition to the general import and export procedures; you will also need to get familiar with the language and the business culture in that particular region. As you can see, there’s quite some learning involved before you can start importing.

How hiring a consultant can help?

A more convenient way to manage all that is to hire an import & export consultant, especially the one who has sufficient knowledge and experience of wholesale trade, shipments, documentation, and the likes. An import & export consultant will be able to help you with all, or some of the following tasks.

A competent import & export consultant can take care of pretty much everything related to wholesale trading while you can focus on other, more important tasks.

Categories: trading

The Fleet Safety Champions Revealed

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Employees and firms who have significantly contributed to fleet risk management have been officially rewarded for their efforts at a gala dinner that was held in Birmingham.

The tenth annual Fleet Safety Forum Awards for Excellence, hosted by Brake, the road safety charity, gives out awards to those that have made significant contributions to road risk management.

Among the winners, Iron Mountain Europe won the Safe Vehicles award, Royal Mail was rewarded for its effort with regards to Fleet Safety Innovation and Nestle Mexico and Interactive Driving Systems received the Fleet Safety Partnership Award.

Brake stated that it had hoped the night which was held at the MacDonald Burlington Hotel, will have raised over 30,000, which will be used primarily to fund the charity’s educational projects and provide support to those bereaved and seriously injured road crash victims.

Furthermore, all fleet operators have to adhere to certain regulations in order to successfully meet safety requirements. These come to include truck side curtain measurements. Truck body manufacturers can give useful advice.

The Fleet Safety Innovation award, which recognises “pioneering approaches” to road safety was given to Royal Mail.

Royal Mail was commended for its “dynamic and continually developing” fleet safety programme, which sets out to achieve an ambitious goal of zero crashes and looks to inspire the use of good practice with other fleets.

The progress made by Royal Mail was reflected in the statistics, where Royal Mail’s crash rate per vehicle fell by 24% over a two year timeline, despite the fact that its fleet increased by more than 14% to over 35,000 vehicles.

Iain McKay of Coca-Cola Enterprises won the Road Risk Manager of the Year for his contribution to road safety both in and outside of the work place.

Mr McKay was the brains behind the success of Coca-Cola’s road safety awareness campaign, overseeing the campaign as it was rolled out as a continuous programme and helped to produce content for it, which came to include over 70 information sheets and six presentations.

Julie Townsend, deputy chief executive at Brake, said: “The Awards are all about recognising hard work, innovation and achievement in fleet safety, and they are a valuable way for us to review and share good practice.

“Throughout the coming year, we will be disseminating case studies on our winners through the Fleet Safety Forum, to inspire and assist other organisations to do more to drive down crashes and casualties. Brake congratulates all the winners for their work to reduce risk, prevent devastating deaths and injuries, and make our roads safer.”

Categories: trading

Animal Models for Therapeutic Strategies

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Model organisms have long been a mainstay of basic and applied research in the life sciences. Among model organisms, it is model animals that have had a central place in medical research and in pharmaceutical and biotechnology company research, including drug discovery, preclinical studies, and toxicology. Although pharmaceutical companies have long employed animal models based on such mammalian species as mice and rats, dogs, cats, pigs, and primates, more recently the pharmaceutical/biotechnology industry has also adopted several invertebrate and lower vertebrate animal models that have emerged from academic laboratories. These animal models include the nematode Caenorhabditis elegans, the fruit fly Drosophila, and the zebrafish. The adoption of invertebrate and zebrafish animal models by industry has been driven by the advent of genomics, especially the finding that not only genes, but also pathways, tend to be conserved during evolution.

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Researchers use animal models in basic research, in developing new therapeutic strategies for treating human diseases, and in drug discovery research (including target identification and validation, drug screening and lead optimization, and toxicity and safety screening), as well as in preclinical studies of drug safety and efficacy. The use of animal models in developing novel therapeutic strategies for human diseases overlaps with basic research that uses animal models to understand physiological and disease pathways. But its aim is to achieve knowledge of pathways and targets in a disease that leads to the development of new paradigms for discovery and development of drugs or other therapeutics. It thus also overlaps with use of animal models in drug discovery. The use of animal models in development of novel therapeutic strategies is the main emphasis of this report.

The creation of new animal models is an important part of animal-based therapeutic strategy research. A major reason why the pharmaceutical/biotechnology industry needs new animal models is because poorly predictive animal models are a major cause of drug attrition during development. This is especially true in therapeutic areas (e.g., oncology and central nervous system [CNS] disease) in which animal models are the most unpredictive. Due to the poor predictivity of many animal models, some researchers would like to work with “human models” based on induced pluripotent stem (iPS) cells. This early stage technology may allow researchers to develop disease models based on cells from people with such genetically determined diseases as spinal muscular atrophy (SMA), Parkinson’s disease, Huntington’s disease, Duchenne and Becker muscular dystrophy, amyotrophic lateral sclerosis (ALS), Executive Summary etc., which more faithfully model the cellular basis of these diseases than animal models. However, most human diseases involve interactions between multiple organs and tissues. Researchers therefore need to continue to use animal models, which are whole, living systems that model physiology-not just cell and molecular biology. Cellular models based on iPS will be used in screening (which may in some cases reduce the numbers of animals needed in a drug discovery program) and to provide information on human disease pathways to supplement information derived from studies with animal models. Information derived from cellular models, and in some cases the cells themselves, may also be used to design new animal models to more faithfully model human diseases.

The final section of Chapter 1 discusses the issue of animal welfare, which is an important consideration in research involving animals. The United States and various European countries, as well as other jurisdictions (national and local), have sets of animal welfare regulations. Central to these regulations is implementation of the 3Rs (Reduction, Refinement, and Replacement.) Academic and corporate research organizations have been incorporating these regulations into their research practices.

However, some types of animal research, especially research involving nonhuman primates, are particularly controversial. Moreover, animal rights activists have had their impact on the practice of animal research, especially in Europe.

The absolutely essential need for animal research for progress in medical science and healthcare is well proven, and researchers and the general public generally support animal research. However, there is an increasing concern for animal welfare, including pressure for research organizations to find ways to reduce the numbers of vertebrate animals used in research. There is also the increasing need for researchers and their organizations to foster open engagement with the public and policy-makers to promote the value of animal research and discuss animal welfare issues.

Chapters 2 through 7 each focus on a particular type of animal model. Chapters 2, 3, 4, and 6 focus on C. elegans, Drosophila, the zebrafish, and the mouse, respectively. Each chapter includes case studies of the use of each of these established animal models in developing novel therapeutic strategies for human disease. Chapters 5 and 7 focus on emerging animal models for use in drug discovery and development of new therapeutic strategies, the African clawed toad Xenopus tropicalis (Chapter 5) and emerging mammalian animal models (Chapter 7). Each of these two chapters focuses on technological developments now in progress to develop tractable animal models based on these organisms for use in drug discovery research. Chapter 7, in addition to the development of model systems based on non-rodent mammals (mainly pigs, ferrets, and marmosets), includes a discussion of the reemergence of the laboratory rat as an animal model. The rat, despite its important uses in physiological research, in studies involving surgery, and in other types of studies, has been eclipsed by the mouse in the post-genomic era. However, it is now “reemerging” as the result of new technologies (e.g., the sequencing of the rat genome and the construction of knockout rats via various novel gene-targeting technologies) and collaborations. Some Animal Models for Therapeutic Strategies of these technologies are also being applied to the development of nonrodent mammalian models.

Chapter 8 discusses the use of computer models and translational biomarkers in helping researchers to more effectively move from preclinical animal studies to human clinical trials. Pharmaceutical and biotechnology company researchers have been increasingly applying pharmacokinetic/pharmacodynamic (PK/PD) modeling to all stages of drug development. This especially includes moving from preclinical animal studies to human clinical trials. These models, as well as biophysical models such as those developed by Novartis and physiological models such as those developed by Entelos, can help researchers more effectively use animal model data in the design of clinical trials. In particular, they can help researchers reduce drug attrition in clinical trials due to suboptimal dosing. Entelos’ virtual NOD mouse model for type 1 diabetes can be described as a “virtual animal model.” This mathematical model is made possible by the extensive studies that have been carried out over 30 years with the living NOD mouse, and the acceptance by the diabetes research community of the usefulness of this mouse model and its relatively faithful modeling of human disease. The virtual NOD mouse is designed to help researchers design more effective animal studies using fewer animals, and hopefully to design more effective and successful clinical trials of agents designed to prevent progression to type 1 diabetes. Nevertheless, the usefulness of the virtual NOD mouse in enabling researchers to discover innovative drugs that achieve proof of concept in clinical trials, let alone reach the market, remains to be confirmed.

Chapter 6, which focuses on the mouse, concludes with a discussion of the issue of developing more predictive animal models of drug efficacy, specifically more predictive mammalian models. The two main reasons for researchers’ difficulties in producing predictive mouse models are 1) differences between the mouse and humans, and 2) major unknown factors in disease biology. These unknown factors have been revealed, for example, by studies in human genetics showing that common variants do not account for most of the heritability of disease, the discovery of the role of copy number variation and of non-coding DNA sequences in human disease determination, and the discovery in recent years of new layers of cellular regulation based on small regulatory RNAs and epigenetics. Although these factors make developing predictive animal models difficult, researchers can use animal models to learn about unknown or poorly understood areas of disease biology. This is expected to lead to the development of improved animal models and the development of new therapeutic strategies and drugs. Researchers can also bridge some of the differences between the mouse and humans by creating humanized mouse models. In some cases, other mammalian species may be better models for certain diseases (e.g., rats for cardiovascular diseases, pigs and ferrets for cystic fibrosis) than the mouse. As discussed in Chapter 7, there are new technologies for producing gene-modified disease models based on these mammalian species.

Developing animal models that are more predictive of efficacy is an iterative process. But progress is being made, as researchers apply new knowledge and experimental approaches Executive Summary in elucidating the biology of particular diseases to creation of animal models. Researchers developing new drugs for complex diseases are well advised to test drugs in more than one animal model and in mouse strains of different genetic backgrounds. They should also, if possible, employ translational efficacy and/or pharmacodynamic biomarkers to link the efficacy seen in preclinical studies with clinical results.

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Categories: trading